Awarded the World’s Most Effective Depigmentation Treatment

Cosmelan by Mesoestetic is a clinical depigmentation method which has an intensive corrective effect on hyperpigmentation, whilst regulating the overproduction of melanin in the melanocytes, inhibiting and controlling the appearance of new dark spots. This treatment works by a dual action-based approach:

Regulating action

Cosmelan works at two levels: At the first level by inhibiting the activation of tyrosinase inside the melanosome, reducing the oxidative stress, and thereby reducing melanin synthesis. Then at a second level, by containing copper chelators (Cu2+) tyrosinase function is reduced. Cosmelan acts by blocking the transfer of the melanosome to the keratinocytes, thereby preventing movement of the pigment to the superficial layers of the skin.

Corrective action

The cosmelan peel reduces the amount of melanin synthesised, reducing the intensity of the dark spot. It also acts on the stratum corneum, stimulating the renewal of the epidermis and intensively eliminating the accumulation of melanin.


You will see a reduction of fine lines & wrinkles, reduced age spots, reduction in discolouration (hyperpigmentation & melasma) leaving a glowing, youthful skin.

Anyone concerned with pigmentation, melasma, sun damage and hyperpigmentation caused from acne can benefit from Cosmelan. It is safe to be performed at any time of year, on new or stubborn pigment deposits, all ages and skin colours.

Expect and plan for 5-7 days downtime with this treatment. The blog post linked below documents an honest experience of the cosmelan® journey in real-time, what it feels like and what to expect post treatment.

Check out our before and after photos to see the results for yourself.

Client Testimonial:

I’d tried multiple treatments in the past to help reduce my pigmentation before taking the plunge to try Cosmelan. Danielle was honest and thorough in her approach to prepare me for this treatment, and made me aware of the serious downtime required — I could not have appreciated this more!

Downtime involved swelling and peeling of the skin, and my face was very red and sore. But after getting through this 7-day period, I saw instant results! Not only did my pigmentation fade, but my skin had a youthful renewed texture and glow! I now don’t feel the need to cover up using makeup, and to this day, I still get compliments on my skin.

Cosmelan isn’t for the faint hearted, but receiving the amazing support, guidance and reassurance via personal check-ins from Danielle; to the LED light therapy included in the days after, made the whole experience worth it. I am so glad I chose Bobbie Charles to guide me through this treatment.

I highly recommend this clinical treatment to those looking for serious results. I’m going on 42 and my skin has a new lease on life!

Service information

Treatment time and frequency:

Cosmelan consists of phase one in-clinic, followed by at-home care with on-going support from your therapist everyday, for the first 5 days post treatment. Your cosmelan journey includes the following appointments in-clinic:

  • First appointment: cosmelan 1 application, 30 mins
  • Second appointment: LED (day 3 post), 30 mins
  • Third appointment: LED (day 7/10 post), 30 mins
  • Fourth appointment: Mesoestetic facial 4 – 6 weeks post (not included in price)

The treatment package includes seven at-home retail products for your post-treatment aftercare (valued at $1,053). You will receive the cosmelan home pack containing products to follow the home protocol of the cosmelan professional method, as well as a home essentials kit. These products are necessary to complete the depigmenting action for removing and/or reducing spots of melanic origin and support your skin post treatment. You will need to commit to 6 months of this treatment journey, following the aftercare, to get optimum results.

The cosmelan treatment can only be repeated every 6 months.

Ideal for: 

  • Hyperpigmentation or melasma
  • Hormonal pigmentation
  • Dull or dehydrated complexion
  • Fine lines and wrinkles
  • Sun damage
  • Skin rejuvenation


  • Pregnancy or breast feeding
  • Recent sunburn
  • Allergies to any of the components of the formulation
  • Treatment with topical or oral prescription strength acne medication
    in the past 6 months
  • Hydroquinone use in the past 3 months on the face
  • Active bacterial, viral, fungal or herpes infection
  • Autoimmune disease and / or chronic imbalances affecting the skin
  • Recent chemotherapy and / or radiotherapy (doctor’s clearance will be required)
  • Recent skin surgery
  • History of keloids or hypertrophic scarring
  • Open or partly open wounds
  • Areas with ink micropigmentation
  • Patients with an unstable psychological profile

Pre-Treatment Requirements:

  • The skin must be super hydrated before the treatment
  • Mesoestetic brightening peel booster applied every night, under moisturiser for 4 weeks before treatment (stop peel booster 5 days before)
  • Hyaluronic acid, applied morning and night for 4 weeks before treatment
  • To prep the skin we highly advise having a lactic peel 2 weeks before the treatment
  • Ensure you are applying a broad-spectrum SPF daily
  • Consult your doctor for an antiviral if you are prone to cold sores

5 days prior to your treatment requirements:

  • No vitamin A / retinol
  • No physical / chemical exfoliating
  • Plenty of hydration minimum 2L p/day
  • Plenty of hyaluronic acid and moisture

Post-Treatment Requirements

Day of application & Days 1 – 6 post treatment:

  • No sweating
  • No makeup
  • No exfoliating or picking any peeling skin
  • No direct sun
  • Minimal heat
  • Follow the strict aftercare regime provided by your Therapist for 6 months post treatment

Day of application (relax, read a book, watch movies, laptop day):

  • No sweating
  • No going outdoors
  • Minimal facial movements
  • No touching your face

Your application appointment will be first up in the morning, as you will have to wear the Cosmelan 1 mask at home for 8-12 hours (your therapist will write the time to remove it on your aftercare sheet).

Expected Side Effects:

  • Swelling and moderate redness
  • Peeling/flaking of the full face
  • Stinging and hot sensation
  • Tightness and moderate discomfort

For new clients that we haven’t yet treated your skin; one peel is required to prepare the skin prior to having this treatment, which isn’t included in the pricing. Please note there is 5-7 days downtime for skin peels.

If you continue to use the Cosmelan 2 cream, you will maintain the results. In some cases where the pigmentation is deep the treatment may need to be repeated – after the first treatment the pigmentation will be much lighter. This treatment is recommended to be repeated every 9-12 months, as pigmentation has such a good memory.

Results can be seen after one treatment of cosmelan. This can be visible in as little as 2 weeks post treatment or otherwise 4-8 weeks post treatment, depending on skin condition and concerns. Maintenance of pigmentation will always be needed due to external and internal factors.

Cosmelan is an intensive treatment which you will need to plan anywhere from 5-7 days of downtime. Your skin will be red, swollen and warm for the first 3 days post treatment, and then peeling will begin. Peeling and dryness can be expected up to 5-7 days. Sun exposure is to be avoided during this time; and an SPF is a MUST to protect your skin and your results. All post care products are included in your treatment price which will help speed up the healing phase.


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